As the Annihilation Wave continues its destructive march across the galaxy, Nova leads a determined resistance backed by the might of champions such as Drax, Ronan and Gamora. However, Annihilus has a new weapon in his arsenal: Galactus, devourer of worlds! Against such might, the resistance seems futile. For the handful who continue to oppose Annihilus, there remains one hope: the mad Titan known as Thanos! Unfortunately, his ancient foe Drax may...